Endocrine Abstracts

Cerebral salt wasting (CSW) occurs as the result of injury to the central nervous system and is most commonly found among those who have experienced a traumatic brain injury (TBI). Although incidence is varied, it has been reported to be as high as 30% within the patient population presenting to hospital with a TBI. CSW causes hyponatremia with concurrent hypovolemia and increased sodium within urine despite normal renal function. Because of its rare nature, CSW is often misdi...

Background: New onset postmenopausal hyperandrogenism (PMH) is rare and is a diagnostic and therapeutic challenge.Clinical Case: AB, a 69-year woman, had 14-years of hirsutism and 1-year of male-pattern balding. Androgen profile was high: testosterone (T) 4.9nmol/L, androstenedione (A) 3.7nmol/L, 17OHP 2.3nmol/L. DHEAS and pre- and post-1 mg ONDST cortisol was normal. Adrenals and ovaries on CT were unremarkable, hence benign ovarian source assumed. She ...

Background and aims: Hypoparathyroidism (HPt) is a rare endocrine disorder often of post-surgical origin, resulting in hypocalcaemia. Several complications have been described including impairment of quality of life (QoL). Our study aims to evaluate the effect of hypoparathyroidism on the Qol of patients diagnosed with HPt.Methods: A cross-sectional study was conducted in the Department of Endocrinology, Diabetology, Metabolic Diseases and Nutrition of t...

Introduction: Amiodarone is a highly effective drug, used for the treatment of arrhythmias. However, it can cause either hypothyroidism or thyrotoxicosis. It leads to alterations in thyroid gland function or thyroid hormone metabolism, due to its high iodine content. Amiodarone-induced hypothyroidism is common in countries with high iodine dietary intake, and Amiodarone-induced thyrotoxicosis is more prevalent in regions with low iodine dietary intake. A large amount of iodide...

Case: A 25-year-old male with a history of Asperger’s syndrome, not on regular medication, with no family history of endocrinopathy; was referred with mild hypercalcaemia found during routine investigations for fatigue, weight loss, diarrhoea and vomiting. A normal PTH suggested PTH-dependent hypercalcaemia. There was no history of fractures or nephrolithiasis. DEXA scan showed normal bone mineral density (femur, spine and forearm). The gastrointestinal symptoms and fatig...

Background: The Glucagon-like peptide-1 receptor agonist (GLP1RA) semaglutide has shown improvements in glycaemia and other metabolic parameters for patients with type 2 diabetes (T2D) in clinical trials. Published real-world data are sparse and there are none from the Middle East where semaglutide became available in 2020.Method and Results: We retrospectively gathered data for 289 patients (median age 50 years (IQR 42-57), 36% female, 87% Emirati and 8...

Background: Acetyl-CoA-Carboxylase (ACC1), the rate-limiting enzyme of de novo lipogenesis, plays a critical role in beta cell growth and insulin secretion. In spite of plethora evidence for the role of ACC1 in insulin secretion and beta cells function both in vivo and in vitro, very little is known about how ACC1 activity is regulated in pancreatic beta cells. The aim of the current study was to screen for novel phospho-sites that may regulate ACC1 activity ...

Introduction: Polycystic ovary syndrome (PCOS) is a complex endocrine disorder of uncertain aetiology, affects 1 in 10 reproductive women and has broad spectrum risks related to reproductive, cardiometabolic and psychosocial health. The wide overlap with other hyperandrogenemic conditions, complexity of PCOS spectrum, and inconsistencies in investigation and management potentially can result in risks of delay in diagnosis and management.Aim: To evaluate ...

Introduction: Diabetic ketoacidosis (DKA) remains a common presentation of type 1 diabetes (T1D) in children. During the COVID-19 pandemic, rates of presentation in DKA increased. Electrolyte abnormalities can occur during DKA treatment, but they are uncommon at presentation. We report a teenage girl with new-onset T1D presenting in severe DKA, complicated by profound hypokalaemia and hypernatremia. Case Report: A previously healthy 13-year-old girl was ...

Background: Biochemical evidence of adrenal insufficiency (AI) is reported commonly during inhaled corticosteroid (ICS) treatment for asthma. The significance of mildly abnormal results is uncertain. For this reason we adopt a stratified approach to the management of patients with impaired cortisol responses to the low dose short Synacthen test (LDSST): Patients with peak cortisol 350–499 nmol/l (‘suboptimal’) receive hydrocortisone 20 mg/m2 per day d...